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C144

Sigma-Aldrich

1-(3-Chlorophenyl)biguanide hydrochloride

solid

Synonym(s):

1-(m-Chlorophenyl)biguanide hydrochloride, N-(3-Chlorophenyl)imidodicarbonimidic diamide hydrochloride, m-CPBG hydrochloride

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About This Item

Linear Formula:
ClC6H4NHC(NH)NHC(NH)NH2 · HCl
CAS Number:
2113-05-5
Molecular Weight:
248.11
MDL number:
MFCD00053019
UNSPSC Code:
12352202
PubChem Substance ID:
24278089
NACRES:
NA.77

form

solid

color

white

mp

190-194 °C (lit.)

solubility

H2O: soluble

SMILES string

Cl[H].NC(=N)NC(=N)Nc1cccc(Cl)c1

InChI

1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H

InChI key

FOWAIJYHRWFTHR-UHFFFAOYSA-N

Gene Information

human ... HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)

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Biochem/physiol Actions

Very potent 5-HT3 serotonin receptor agonist.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCD2737
SLCB1913
SLBS8107
SLBN9992V
SLBF8520V

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Zachary A Rodd et al.
The Journal of pharmacology and experimental therapeutics, 321(3), 1003-1012 (2007-02-28)
Studies from our laboratory indicated that local perfusion of the ventral tegmental area (VTA) with a serotonin-3 (5-HT(3)) receptor agonist increased dopamine (DA) neuronal activity and that the self-infusion of ethanol (EtOH) and cocaine into the posterior VTA could be
Borna Payandemehr et al.
Epilepsy research, 101(3), 217-227 (2012-05-15)
Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders. It has been shown that citalopram affects seizure susceptibility. Although the exact mechanism of these effects are not yet fully understood, recent data suggest
Jaime M Monti et al.
Progress in neuro-psychopharmacology & biological psychiatry, 32(4), 940-947 (2008-02-26)
The effects of the selective 5-HT(3) receptor agonist and antagonist m-chlorophenylbiguanide (m-CPBG) and ondansetron, respectively, were studied in adult male Wistar rats implanted for chronic sleep recordings. Microinjection of m-CPBG (2.0 and 4.0 mM) into the dorsal raphe nucleus (DRN)
Philip M Lang et al.
Journal of neurophysiology, 96(6), 2963-2971 (2006-09-08)
Activity-dependent fluctuations in axonal excitability and changes in interspike intervals modify the conduction of trains of action potentials in unmyelinated peripheral nerve fibers. During inflammation of a nerve trunk, long stretches of axons are exposed to inflammatory mediators such as
Jaime M Monti et al.
Progress in neuro-psychopharmacology & biological psychiatry, 35(5), 1341-1348 (2011-04-26)
The effects of the selective 5-HT(3) receptor agonist m-chlorophenylbiguanide (m-CPBG), and of the NMDA (N-methyl-D-aspartate) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate)/kainate antagonists AP-5 [(±)-2-amino-5-phosphono-pentanoic acid] and CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), respectively, were studied in adult male Wistar rats implanted for chronic sleep recordings. The
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