Continuous In-Line Virus Inactivation for Next Generation Bioprocessing

WEBINAR

Adoption of intensified, integrated, continuous processing has increased as the biomanufacturing community drives innovation and advances enabling technology. To enable fully continuous downstream, an automated low-pH inline Virus Inactivation system was developed implementing a single-use flowpath with coiled flow inverter incubation chambers. The system controls pH and residence time, employing a residence time distribution model built from a large dataset. Comparability of viral inactivation and process performance in inline versus batch modes has been demonstrated. The incubation chambers offer potential to convert from batch to continuous for other bioprocesses requiring a hold time. 

In this webinar, you will learn how:

• Coiled-flow inverter incubation chambers provide an efficient, well-characterized residence time to convert static hold operations to continuous flow.
• Bench-scale chambers and method allow evaluation of low pH inline viral inactivation operation and comparison to process-scale performance.
• Continuous connected capture integrating multi column chromatography with low pH inline viral inactivation delivers effective process control with high product yield and quality.