Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

92361

Sigma-Aldrich

Chlorotrimethylsilane

≥98.0% (GC)

Synonym(s):

TMCS, Trimethylchlorosilane, Trimethylsilyl chloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
(CH3)3SiCl
CAS Number:
75-77-4
Molecular Weight:
108.64
Beilstein:
1209232
EC Number:
200-900-5
MDL number:
MFCD00000502
UNSPSC Code:
12352302
PubChem Substance ID:
57653472
NACRES:
NA.22

vapor density

3.7 (vs air)

vapor pressure

100 mmHg ( 25 °C)

Assay

≥98.0% (GC)

form

liquid

autoignition temp.

752 °F

expl. lim.

6.4 %

refractive index

n20/D 1.387 (lit.)

bp

57 °C (lit.)

mp

−40 °C (lit.)

density

0.856 g/mL at 25 °C (lit.)

SMILES string

C[Si](C)(C)Cl

InChI

1S/C3H9ClSi/c1-5(2,3)4/h1-3H3

InChI key

IJOOHPMOJXWVHK-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.

Application

Chlorotrimethylsilane has been used to silanize glass surface to make them more hydrophobic. It can be used in combination with hexamethyldisilazane for the protection of alcohols by forming trimethylsilyl ethers via silylation reaction. Also used in Fisher Glycosylation

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A

Supplementary Hazards

EUH014

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-18.4 °F - closed cup

Flash Point(C)

-28 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Thermal analysis of disulfonated poly (arylene ether sulfone) plasticized with poly (ethylene glycol) for membrane formation.
Oh HJ, et al.
Polymer, 55(1), 235-247 (2014)
Science of Synthesis: Houben-Weyl Methods of Molecular Transformations, 4, 261-261 (2014)
Yongju Kwon et al.
Nature communications, 11(1), 3127-3127 (2020-06-21)
Magic-sized clusters (MSCs) can be isolated as intermediates in quantum dot (QD) synthesis, and they provide pivotal clues in understanding QD growth mechanisms. We report syntheses for two families of heterogeneous-atom-incorporated InP MSCs that have chlorine or zinc atoms. All
Yuma Komata et al.
Chemistry, an Asian journal, 11(22), 3225-3233 (2016-10-21)
Alkoxychlorosilanes are scientifically and industrially important toward preparing silicone and silica as well as preparation of siloxane-based nanomaterials by stepwise reactions of Si-OR (R=alkyl) and Si-Cl groups. Intermolecular exchange of alkoxy and chloro groups between alkoxysilanes and chlorosilanes (functional group
Use of organosilicon reagents as protective groups in organic synthesis.
Lalonde M & Chan TH.
Synthesis, 1985(09), 817-845 (1985)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service