1.19163

Caffeine standard solution for HPLC system qualification

Solution for gradient test; 20 mg/l caffeine in water 500 ml LiChroTest^™

• Synonym(s): Caffeine Calibration Solution for HPLC
• UNSPSC Code: 41115709
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• form: liquid
• technique(s): HPLC: suitable
• pH: 5 (20 °C in H₂O)
• density: 1.000 g/cm³ at 20 °C
• storage temp.: 15-25°C

Description

Application

• Ultra-high performance liquid chromatography-tandem mass spectrometry for genotoxic impurities: Gong et al. utilized caffeine standard solutions in ultra-high performance liquid chromatography (UHPLC) tandem mass spectrometry to determine dimethyl sulfate in tertiary amine drugs, demonstrating the standard′s critical role in accurate system qualification and ensuring pharmaceutical safety (Gong et al., 2022).


• Rapid determination of functional components in cosmetics: Xiong et al. employed a caffeine standard solution in ultra-high performance liquid chromatography coupled with a linear ion trap/orbitrap for the rapid determination of 22 functional components in cosmetics, showcasing the standard′s utility in high-resolution mass spectrometry for complex mixture analysis (Xiong et al., 2022).


• Molecular absorption spectroscopy for pharmaceutical analysis: Tran et al. used caffeine standard solutions in a study combining molecular absorption spectroscopy with classical least square methods to simultaneously determine multiple compounds in pharmaceutical tablets, illustrating the importance of high-purity standards in method validation and system calibration (Tran et al., 2022).

Analysis Note

20 mg/l caffeine: in accordance

Legal Information

LICHROTEST is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable