324473

PARP Inhibitor IX, EB-47

The PARP Inhibitor IX, EB-47 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(s): PARP Inhibitor IX, EB-47
• Empirical Formula (Hill Notation): C₂₄H₂₇N₉O₆ · 2HCl · 2H₂O
• Molecular Weight: 646.48
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• potency: 45 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 50 mg/mL
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of PARP-1 (IC₅₀ = 45 nM). Shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.

A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) (IC₅₀ = 45 nM). Reported to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PARP-1

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett.14, 81.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable