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L0665

Sigma-Aldrich

Lambda Light Chains (Free) from human myeloma sera

purified immunoglobulin, ~1.0 mg/mL, ≥99% (Purity by double diffusion), buffered aqueous solution

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

human

Quality Level

antibody form

purified immunoglobulin

Assay

≥99% (Purity by double diffusion)

form

buffered aqueous solution

concentration

~1.0 mg/mL

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

Immunoglobulins (Ig) are produced by the B cells and play crucial role in host humoral immune response. A typical immunoglobulin consists of two heavy chains and two light chains. The two light chains are either κ or the λ chain. The B cells express one type of light chain during their life time
λ Light Chains (Free) from human myeloma sera consists of IgG λ light chains purified from myeloma sera.

Application

λ Light Chains (Free) from human myeloma sera may be used as immunoglobulin calibrator, blocking agent or coating protein in various immunoassays.

Physical form

Solution in 0.01 M phosphate and 0.15 M sodium chloride, pH 7.2, containing 1.0 M glycine and 0.1% sodium azide.

Preparation Note

Purified from pooled IgG lambda myeloma sera.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Jerry A Katzmann et al.
Clinical chemistry, 48(9), 1437-1444 (2002-08-27)
The detection of monoclonal free light chains (FLCs) is an important diagnostic aid for a variety of monoclonal gammopathies and is especially important in light-chain diseases, such as light-chain myeloma, primary systemic amyloidosis, and light-chain-deposition disease. These diseases are more

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