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Key Documents

SAE0154

Sigma-Aldrich

E64 Ready Made solution

Non-freezing solution, 1 mg/mL

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.54

Quality Level

form

ready-to-use solution

shipped in

wet ice

storage temp.

−20°C

General description

E-64 is a cysteine protease inhibitor that effectively inhibits various cysteine proteases such as: cathepsin K, cathepsin L, cathepsin S known also as N-[N-(L-3-trans-carboxyoxiran-2-carbonyl)-L-leucyl]-agmatine, E-64 was isolated from the mold Aspergillus japonicus TPR-64.

Biochem/physiol Actions

E-64 is an highly selective, potent and irreversible cysteine protease inhibitor. The trans-epoxysuccinyl group of E-64 is its active moiety, and irreversibly binds to an active thiol group of many cysteine proteases, such as papain, actinidase, and cathepsins B, H and L, to form a thioether linkage.

Preparation Note

This E-64 Ready Made Solution is supplied as a proprietary 2.8 mM non-freezing solution formulation.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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