T6829

TUG-424

≥98% (HPLC)

• Synonym(s): 3-(4-(o-Tolylethynyl)phenyl)propanoic acid
• Empirical Formula (Hill Notation): C₁₈H₁₆O₂
• CAS Number: 1082058-99-8
• Molecular Weight: 264.32
• MDL number: MFCD12912449
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826854
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Cc1ccccc1C#Cc2ccc(CCC(O)=O)cc2
• InChI: 1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
• InChI key: FODHWOBAQBTTFS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.

GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H319,H410
• Precautionary Statements: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves