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  • A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis.

A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis.

Organic letters (2003-02-26)
Jill M McFadden, Gojeb L Frehywot, Craig A Townsend
ABSTRACT

[formula: see text] A new and efficient asymmetric synthesis of naturally occurring (5R)-thiolactomycin (1) using D-alanine as the source of chirality is described.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(R)-(+)-2-Chloropropionic acid, 99%