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  • Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms.

Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms.

Natural product reports (2013-10-25)
Gwilherm Evano, Cédric Theunissen, Alexandre Pradal
ABSTRACT

Copper-catalyzed Ullmann-Goldberg-type cross-coupling reactions have undergone nothing short of a renaissance over the last decade and an impressive number of procedures are now available for the formation of C-N, C-O and C-S bonds with remarkable efficiencies and surgical precision. These reactions have been recently integrated into natural product synthesis, which clearly resulted in the emergence of new retrosynthetic paradigms and bond disconnections. The impact of copper-catalyzed cross-coupling reactions in natural product synthesis will be overviewed in this article with an emphasis on the evolution of strategies due to copper catalysis, mostly by comparison with alternative tactics and their relative efficiencies.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Copper, beads, 2-8 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Copper, foil, thickness 1.0 mm, 99.999% trace metals basis
Sigma-Aldrich
Copper, beads, 2-8 mm, 99.9995% trace metals basis
Continuous cast copper (O), BCR®, certified reference material, rod
Sigma-Aldrich
Copper, turnings, purum p.a., ≥99.0%
Sigma-Aldrich
Copper, foil, thickness 0.025 mm, 99.98% trace metals basis
Sigma-Aldrich
Copper, wire, diam. 0.25 mm, 99.999% trace metals basis
Sigma-Aldrich
Copper, foil, thickness 0.5 mm, 99.98% trace metals basis
Sigma-Aldrich
Copper, wire, diam. 1.0 mm, ≥99.9%
Sigma-Aldrich
Copper, wire, diam. 0.64 mm, 99.995% trace metals basis
Copper, rod, 100mm, diameter 16mm, as drawn, 99.99+%
Sigma-Aldrich
Copper, foil, ≥99.8% (complexometric)
Sigma-Aldrich
Copper, powder, <75 μm, 99%
Sigma-Aldrich
Copper, wire, diam. 2.0 mm, 99.999% trace metals basis
Copper, tube, 1000mm, outside diameter 5.0mm, inside diameter 4mm, wall thickness 0.5mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 6.0mm, inside diameter 4mm, wall thickness 1.0mm, as drawn, 99.9%
Copper, rod, 50mm, diameter 6.35mm, as drawn, 99.999%
Copper, tube, 100mm, outside diameter 1.75mm, inside diameter 0.33mm, wall thickness 0.71mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 12.7mm, inside diameter 10.26mm, wall thickness 1.22mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.25mm, half hard, 99.95+%
Copper, wire reel, 100m, diameter 0.025mm, as drawn, 99.99+%
Copper - O.F.H.C., foil, 25mm disks, thickness 0.7mm, half hard, 99.95+%
Copper, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.999%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.5mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 6mm disks, thickness 0.006mm, hard, 99.95+%
Copper, wire reel, 100m, diameter 0.02mm, hard, 99.99+%
Copper - O.F.H.C., foil, 2m coil, thickness 0.125mm, hard, 99.95+%
Copper - O.F.H.C., foil, 25mm disks, thickness 1.0mm, half hard, 99.95+%
Copper, wire reel, 5m, diameter 0.5mm, as drawn, 99.98+%
Copper - O.F.H.C., foil, 2m coil, thickness 0.7mm, half hard, 99.95+%