- Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid.
Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid.
Molecules (Basel, Switzerland) (2010-07-27)
Xiao Jia Yin, Guan Hong Xu, Xu Sun, Yan Peng, Xing Ji, Ke Jiang, Fei Li
PMID20657439
ABSTRACT
This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC.
MATERIALS