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H2904

Sigma-Aldrich

HistoChoice® Tissue Fixative

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.47

color

colorless

Quality Level

100

application(s)

hematology
histology

storage temp.

room temp

Application

Designed for the molecular biologist. Specially formulated to preserve antigenic sites for antibody probes and nucleic acid sites for in situ hybridizations. Fixed sections do not require predigestion or other recovery procedures to make important sites available.

Quality

Contains no formaldehyde, glutaraldehyde or mercury. Non-toxic

Legal Information

HistoChoice is a registered trademark of Amresco, Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCF1631
MKCD7982
MKCC6734
MKBZ8940V
MKBS3694V

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D G Vince et al.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology, 15(2), 119-129 (1997-01-01)
Formaldehyde fixatives have traditionally been used to preserve tissues as they impart excellent morphological preservation. Formaldehyde fixes tissue by cross linking, a process which can reduce the antigenicity of tissue and weakens the intensity of immunohistochemical stains. Preliminary studies have
M A Kacena et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 79(5-6), 185-190 (2005-03-15)
We compared histochemical and immunohistochemical staining as well as fluorochrome labeling in murine bone specimens that were fixed with 10% neutral buffered formalin to those fixed with HistoChoice. We showed that sections from undecalcified tibiae fixed for 4 h in
J Melrose et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 83(1), 47-53 (2008-06-24)
Histochoice is a proprietary nontoxic, non-cross-linking fixative designed by the manufacturer to replace formaldehyde based fixation protocols. We compared Histochoice and formalin fixation for several cartilaginous tissues including, articular and growth plate cartilage, meniscus and intervertebral disc. The tissues were
Yan Levitsky et al.
International journal of molecular sciences, 21(11) (2020-06-03)
Mitochondrial damage in the cells comprising inner (retinal endothelial cells) and outer (retinal pigment epithelium (RPE)) blood-retinal barriers (BRB) is known to precede the initial BRB breakdown and further histopathological abnormalities in diabetic retinopathy (DR). We previously demonstrated that activation
Erik P Rader et al.
Aging cell, 17(5), e12816-e12816 (2018-07-12)
Snell dwarf mice (Pit1dw/dw ) exhibit deficiencies in growth hormone, prolactin, and thyroid stimulating hormone. Besides being an experimental model of hypopituitarism, these mice are long-lived (>40% lifespan extension) and utilized as a model of slowed/delayed aging. Whether this longevity
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