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C9008

Sigma-Aldrich

p-Coumaric acid

≥98% purity (HPLC), powder

Synonym(s):

trans-4-Hydroxycinnamic acid

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About This Item

Linear Formula:
HOC6H4CH=CHCO2H
CAS Number:
Molecular Weight:
164.16
Beilstein:
2207383
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

product name

p-Coumaric acid, ≥98.0% (HPLC)

Assay

≥98.0% (HPLC)

form

powder

color

white to yellow

mp

214 °C (dec.) (lit.)

solubility

ethanol: 50 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

OC(=O)\C=C\c1ccc(O)cc1

InChI

1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+

InChI key

NGSWKAQJJWESNS-ZZXKWVIFSA-N

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Application

p-Coumaric acid has been used as a component of chemiluminescent substrate for protein detection in western blotting.

Biochem/physiol Actions

In western blot, p-coumaric is also used as an enhancer in chemiluminescent substrate.
Hydroxycinnamic acid found in many fruits and vegetables.

Other Notes

Predominantly trans isomer.

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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Enhanced chemiluminescence (ECL) for routine immunoblotting: An inexpensive alternative to commercially available kits.
Mruk DD and Cheng CY
Spermatogenesis, 1, 121-122 (2011)
A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background.
Haan C and Behrmann I
Journal of Immunological Methods, 318, 11-11 (2007)
Inflammation triggers high mobility group box 1 (HMGB1) secretion in adipose tissue, a potential link to obesity.
Gunasekaran MK, et al.
Cytokine, 64, 103-111 (2013)
p-Coumaric acid kills bacteria through dual damage mechanisms.
Zaixiang L, et al.
Food Control, 25, 550-554 (2012)
TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-beta.
Rojas A, et al.
Biochimica et Biophysica Acta, 1793, 1165-1173 (2009)

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