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E2250

Sigma-Aldrich

Ellagic acid

≥95% (HPLC), powder, from tree bark

Synonym(s):

4,4′,5,5′,6,6′-Hexahydroxydiphenic acid 2,6,2′,6′-dilactone, Alizarin Yellow, Benzoaric acid, Elagostasine, Eleagic acid, Gallogen, Lagistase

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About This Item

Empirical Formula (Hill Notation):
C14H6O8
CAS Number:
Molecular Weight:
302.19
Beilstein:
47549
EC Number:
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.77

biological source

tree bark

Assay

≥95% (HPLC)

form

powder

shelf life

5 yr

solubility

1 M NaOH: 10 mg/mL

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

Oc1cc2C(=O)Oc3c(O)c(O)cc4C(=O)Oc(c1O)c2-c34

InChI

1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H

InChI key

AFSDNFLWKVMVRB-UHFFFAOYSA-N

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General description

Ellagic acid is a naturally occurring phenolic acid in many fruits and vegetables, as a secondary plant metabolite. It is commonly found in green tea, pomegranate, strawberries, blackberries, raspberries, and walnuts.

Application

Ellagic acid has been used:
  • to study the metabolism of dietary phenolic acids by Lactobacillus plantarum CECT 748T
  • as a potential substrate for the high production of Lactobacillus plantarum tannase
  • as a standard in the study to examine the phenolic components and anti-oxidant activity of nettle
  • to study the links between dietary ellagic acid and epigenetic modulation of adipogenesis

Biochem/physiol Actions

Ellagic acid has been found to exhibit antioxidant activity by virtue of having an inhibitory effect on the oxidation of low-density lipoproteins. This makes them have a cardioprotective effect on humans. In addition, it shows anticarcinogenic, antifibrotic, antiplasmodial, apoptotic, and chemopreventive activities as well.
Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma. Contact activation in blood coagulation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H Hayatsu et al.
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Dietary inhibitors of mutagenesis and carcinogenesis are of particular interest because they may be useful for human cancer prevention. Several mutagenesis inhibitors have been demonstrated to be carcinogenesis inhibitors also, e.g., ellagic acid, palmitoleic acid, and N-acetylcysteine. This means that
Detecting oral kallikrein-targeting therapy through triggered contact activation: A phase I study.
Zonne L M Hofman et al.
The Journal of allergy and clinical immunology, 146(6), 1446-1449 (2020-05-04)
Inhae Kang et al.
The Journal of nutritional biochemistry, 25(9), 946-953 (2014-06-16)
Chromatin remodeling is a key mechanism in adipocyte differentiation. However, it is unknown whether dietary polyphenols are epigenetic effectors for adiposity control. Ellagic acid (EA) is a naturally occurring polyphenol in numerous fruits and vegetables. Recently, EA-containing foods have been
Metabolism of food phenolic acids by Lactobacillus plantarum CECT 748T
Rodriguez H, et al.
Food Chemistry, 107(4), 1393-1398 (2008)
Antioxidant interactions of catechin, cyanidin, caffeic acid, quercetin, and ellagic acid on human LDL oxidation
Meyer AS, et al.
Food Chemistry, 61(1-2), 71-75 (1998)

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