Technical Article

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Showing 1-30 of 2015 results

Syntheses of Functionalized Alkenes, Arenes, and Cycloalkenes via a Hydroboration-Coupling Sequence

Tandem hydroboration Suzuki Coupling both intermolecular and intramolecular gave diverse alkyl substituted products dppf

Deoxyfluorination with 2-Pyridinesulfonyl Fluoride (PyFluor)

The prevalence of organofluorine compounds in industry and drug design necessitates the ability to introduce C–F bonds to molecules.

Self-Assembled Monolayers: Advantages of Pure Alkanethiols

We presents an article regarding Self-Assembled Monolayers: Advantages of Pure Alkanethiols.

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

Quantum Dots: An Emerging Class of Soluble Optical Nanomaterials

We presents an article concering Quantum Dots: An Emerging Class of Soluble Optical Nanomaterials.

p53: DNA Damage Response and Cancer

p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.

Centrifugation-free Protein Extraction and Purification from Total Cultures of Baculovirus-infected Insect Cells

Catalysts for Carbonylation

Professor Geoffrey Coates and co-workers at Cornell University have reported the preparation and use of catalysts composed of an oxophilic Lewis acid and a cobalt tetracarbonyl anion for the ring expansive carbonylation of epoxides to b-lactones and b-lactones to succinic

1-hydrosilatrane

As a versatile hydride reagent, 1-hydrosilatrane can be used in reduction reactions to synthesize alcohols, amines, their chiral counterparts, and esters from aldehydes/ketones.

Anti-FLAG® M2 Magnetic Beads

Comparison of elution techniques for small-scale protein purification of FLAG® tag proteins using anti-FLAG® M2 magnetic beads.

Automated IgG Purification Using PureProteom

PureProteome™ Protein A and G Magnetic beads provide a rapid and reproducible means to purify immunoglobulins (IgG) using the KingFisher Duo particle processor.

ChIP Troubleshooting Tips

Chromatin Immunoprecipitation (ChIP) Troubleshooting Tips

RPC Purification Options and Scale up with SOURCE™ Media

The different stages of working with SOURCE™ (Cytiva) for high-resolution separation are discussed, from purification to polishing and scaling up

Nanodisc Technology: A Revolutionary System for Study of Membrane Proteins

Read our article about how the Nanodisc system allows for structural studies of membrane proteins.

Detection of Campylobacter spp. and Enterobacter Sakazakii in Food with a New Test Kit System

Detection of Campylobacter spp. and Enterobacter sakazakii in food with a new test kit system.

Nanostructured Olivine-based Cathode Materials for Lithium-ion Batteries

Due to the adverse impact of the continued use of fossil fuels on the earth’s environment and climate, researchers have been asked to develop new approaches for producing power using renewable sources like wind and solar energy

Recent Developments in Magnetic Iron Oxide Nanoparticles for Non-Invasive Bioimaging

Professor Hui Mao explores the use of superparamagnetic iron oxide nanoparticles (INOPs) that offer an alternate contrast-enhancing mechanism.

Primary Human Epidermal Keratinocytes Cell Culture System

Primary human keratinocytes and serum-free keratinocyte growth media for the feeder cell-free in vitro cultivation of epidermal keratinocytes. Protocols for handling, cell passaging, media, and product use.

Validation of RNAi Knockdown Using Multiple Reaction Monitoring and Protein-AQUA

The field of proteomics is continually looking for new ways to investigate protein dynamics within complex biological samples. Recently, many researchers have begun to use RNA interference (RNAi) as a method of manipulating protein levels within their samples, but the

ChIC/CUT&RUN Kits

Chromatin Immunocleavage (ChIC) kits and CUT&RUN technology overview for improved chromatin isolation and downstream analyses.

Organic Semiconductor Laser Materials

Self-Propagating Reactions Induced by Mechanical Alloying

An article concerning self-propagating reactions induced by mechanical alloying, presented by Sigma-Aldrich.com.

Materials Design Concepts for Efficient Blue OLEDs: A Joint Theoretical and Experimental Study

Vitronectin

Vitronectin is a glycoprotein present in plasma and tissues. Together with fibronectin, vitronectin is one of the major cell adhesion proteins in plasma.

Tetrakis(dimethylamino)ethylene (TDAE)

In 2001, Professor William Dolbier, Jr., at the University of Florida reported1 an approach to nucleophilic trifluoromethylation based on the generation of a trifluoromethyl anion using CF3I in the presence of a powerful twoelectron reductant, tetrakis(dimethylamino)ethylene (TDAE)

FastWoRX for Faster and Greener Alternative to Liquid-Liquid Extraction

Bioanalysis with SPME

Biocompatible SPME devices employ C18 bonded porous silica sorbent particles, in a binder which resists fouling by biological matrix components

radiello® Diffusive Air Sampling Application - Ammonia

Chiral Quest Phosphine Ligands

Sigma-Aldrich has research quantities of a series of Zhang’s chiral phosphines for catalytic asymmetric hydrogenations.

Ultra-High Performance Liquid Chromatography (UHPLC) with the Ascentis® Express Phenyl-Hexyl Column

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