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Sigma-Aldrich

2,5-Dichloro-1,4-benzoquinone

98%

Synonym(s):

2,5-Dichloro-2,5-cyclohexadiene-1,4-dione, 2,5-Dichloro-p-benzoquinone

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About This Item

Empirical Formula (Hill Notation):
C6H2Cl2O2
CAS Number:
615-93-0
Molecular Weight:
176.98
EC Number:
210-453-8
MDL number:
MFCD00041736
UNSPSC Code:
12352100
PubChem Substance ID:
24867059
NACRES:
NA.22

Assay

98%

mp

160-163 °C (lit.)

SMILES string

ClC1=CC(=O)C(Cl)=CC1=O

InChI

1S/C6H2Cl2O2/c7-3-1-5(9)4(8)2-6(3)10/h1-2H

InChI key

LNXVNZRYYHFMEY-UHFFFAOYSA-N

General description

2,5-Dichloro-1,4-benzoquinone (DCBQ) is a halogenated quinone. DCBQs are carcinogenic intermediates.They have benn identified as chlorination disinfection byproducts in drinking water. DCBQ has been reported to increse the decomposition of a model ROOH tert-butylhydroperoxide, via formation of t-butoxyl radicals. The isomers of the DCBQ dimer have been investigated for the non-covalent interactions (NCIs) by quantum chemical calculations. Halogen bond present in 2,5-dichloro-1,4-benzoquinone have been investigated by experimental as well as theoretical charge density analysis. Its reaction with pyrrolidine has been investigated.

Application

2,5-Dichloro-1,4-benzoquinone may be used in the following processes:
  • As a starting material in the synthesis of asterriquinone D.
  • As a model to study the utility of a novel photoreactor with LED (light-emitting diode) light source and a fibre-optic CCD (charge-coupled device) spectrophotometer.
  • 2,5-dichloro-3,6-bi(3-indolyl)-1,4-hydroquinone synthesis by palladium catalyzed reaction with indole.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chun-Hua Huang et al.
Chemical research in toxicology, 28(5), 831-837 (2015-03-20)
Halogenated quinones (XQ) are a class of carcinogenic intermediates and newly identified chlorination disinfection byproducts in drinking water. Organic hydroperoxides (ROOH) can be produced both by free radical reactions and enzymatic oxidation of polyunsaturated fatty acids. ROOH have been shown
Halogen bonding in 2, 5-Dichloro-1, 4-benzoquinone: Insights from experimental and theoretical charge density analysis.
Hathwar VR, et al.
Crystal Growth & Design, 11(5), 1855-1862 (2011)
B Vijaya Pandiyan et al.
Physical chemistry chemical physics : PCCP, 16(37), 19928-19940 (2014-08-15)
The competition between non-covalent interactions (NCIs), such as C-H∙∙∙O, C-H∙∙∙Cl, C-Cl∙∙∙O, C-Cl∙∙∙Cl-C, C-O∙∙∙C, C-Cl∙∙∙C and C-O∙∙∙π, in the isomers of the 2,5-dichloro-1,4-benzoquinone (DCBQ) dimer were investigated by quantum chemical calculations to study the properties of the ground and excited states.
Unexpected Reaction of 2,5-Dichloro-1,4-benzoquinone with Pyrrolidine.
Chapyshev SV and Ibata T.
Mendeleev Communications, 4(4), 150-152 (1994)
A facile synthesis of asterriquinone D.
Tanoue Y, et al.
Journal of Heterocyclic Chemistry, 45(5), 1509-1509 (2008)
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