731129

N-Isopropylacrylamide

≥99%

• Synonym(s): NIPAM
• Linear Formula: H₂C=CHCONHCH(CH₃)₂
• CAS Number: 2210-25-5
• Molecular Weight: 113.16
• EC Number: 218-638-5
• MDL number: MFCD00041913
• UNSPSC Code: 12162002
• PubChem Substance ID: 329764623
• NACRES: NA.23

Properties

• Assay: ≥99%
• form: flakes
• bp: 89-92 °C/2 mmHg (lit.)
• mp: 60-63 °C (lit.); 63-67 °C
• storage temp.: 2-8°C
• SMILES string: CC(C)NC(=O)C=C
• InChI: 1S/C6H11NO/c1-4-6(8)7-5(2)3/h4-5H,1H2,2-3H3,(H,7,8)
• InChI key: QNILTEGFHQSKFF-UHFFFAOYSA-N

Description

General description

N-Isopropylacrylamide (NIPAM) is a biocompatible monomeric unit that can be used in the formation of stimuli responsive polymers due to its temperature sensitive properties. These properties include temperature based volumetric and phase changes, which change when the temperature of the solution reaches a lower critical solution temperature (LCST).

Application

NIPAM can be used to prepare poly(NIPAM) for a variety of applications such as tissue engineering, cell culture, biomedical coating, drug delivery, and muscle regeneration.

N-Isopropylacrylamide can also be used as a key component in:

• The synthesis of self-powered multifunctional organic hydrogel based on poly(acrylic acid-N-isopropyl acrylamide) for flexible sensing devices.
• The development of a new type of flexible and stable gel electrolyte for aqueous Zn-MnO₂ batteries.
• The preparation of poly(N-isopropylacrylamide/itaconic acid) (PNIPAM/IA) copolymeric hydrogels for drug delivery applications.
• The synthesis of poly(N-isopropylacrylamide) (PNIPAM) polymer for the development of a new class of polymer-grafted semiconductor devices.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H318
• Precautionary Statements: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3