C7017

Choline chloride

≥99%

• Synonym(s): (2-Hydroxyethyl)trimethylammonium chloride
• Linear Formula: (CH₃)₃N(Cl)CH₂CH₂OH
• CAS Number: 67-48-1
• Molecular Weight: 139.62
• Beilstein: 3563126
• EC Number: 200-655-4
• MDL number: MFCD00011721
• UNSPSC Code: 50501514
• PubChem Substance ID: 57654039
• NACRES: NA.25

Properties

• biological source: synthetic
• Assay: ≥99%
• form: powder
• color: white
• mp: 302-305 °C (dec.) (lit.)
• lipid type: phospholipids
• SMILES string: [Cl-].C[N+](C)(C)CCO
• InChI: 1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
• InChI key: SGMZJAMFUVOLNK-UHFFFAOYSA-M

Description

General description

Choline is a constituent of sphingomyelin and lecithin. It is a precursor of acetylcholine. Choline plays a vital role in methyl group metabolism, carcinogenesis and lipid transport. Choline deficiency is associated with fatty liver. It maintains cell structural integrity and cell signalling. Choline is implicated in the synthesis of phospholipids. It acts as a potent biomarker for ischemic heart disease.

Application

Choline chloride has been used:

• in choline release assay
• as an endogenous agonist of sigma-1 receptors (Sig-1Rs)
• as a standard to analyse interrelationships between methionine and choline metabolism

Biochem/physiol Actions

Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.

Substrates

Choline acetyltransferase substrate

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves