G7637

Guanosine 5′-[β-thio]diphosphate trilithium salt

≥85% (HPLC), powder

• Synonym(s): GDPβS trilithium salt, GDP-β-S, GDP-β-S-Li₃
• Empirical Formula (Hill Notation): C₁₀H₁₂Li₃N₅O₁₀P₂S
• CAS Number: 97952-36-8
• Molecular Weight: 477.07
• Beilstein: 8181243
• MDL number: MFCD00057735
• UNSPSC Code: 41106305
• PubChem Substance ID: 329799966
• NACRES: NA.77

Properties

• Assay: ≥85% (HPLC)
• form: powder
• color: white
• solubility: H₂O: 20 mg/mL (Solutions are very unstable; prepare immediately prior to use.)
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H15N5O10P2S.3Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(24-9)1-23-26(19,20)25-27(21,22)28;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H2,21,22,28)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1
• InChI key: LMCWQGPJYZRMKU-CYCLDIHTSA-K

Description

Application

Guanosine 5′-[β-thio]diphosphate trilithium salt has been used as an inhibitor of G-protein activation to study its effects on acetylcholine current in bag cell neurons. It has also been used to study its effects on cholinergic-dependent plateau potentials.

Biochem/physiol Actions

Guanosine 5′-[β-thio]diphosphate is a non-hydrolyzable analog of guanosine. It functions as an inhibitor of G-protein activation.

Features and Benefits

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Linkage

Non-hydrolyzable GDP analog

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable