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  • An unusual reactivity of BBr(3): Accessing tetrahydroisoquinoline units from N-phenethylimides.

An unusual reactivity of BBr(3): Accessing tetrahydroisoquinoline units from N-phenethylimides.

Organic & biomolecular chemistry (2010-07-29)
Jayaraman Selvakumar, Alexandros Makriyannis, Chinnasamy Ramaraj Ramanathan
ABSTRACT

Isoindoloisoquinalinone, pyrroloisoquinolinone and benzo[a]quinolizinone units are constructed via intramolecular cyclization of the methoxy substituted N-phenethylimides using BBr(3).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Boron trichloride solution, 1.0 M in methylene chloride
Sigma-Aldrich
Boron trichloride solution, 1.0 M in heptane
Sigma-Aldrich
Boron trichloride solution, 1.0 M in toluene
Sigma-Aldrich
Boron trichloride solution, 1.0 M in p-xylene