Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.

Science advances (2021-10-21)

Andry Andrianarivelo, Estefani Saint-Jour, Paula Pousinha, Sebastian P Fernandez, Anna Petitbon, Veronique De Smedt-Peyrusse, Nicolas Heck, Vanesa Ortiz, Marie-Charlotte Allichon, Vincent Kappès, Sandrine Betuing, Roman Walle, Ying Zhu, Charlène Joséphine, Alexis-Pierre Bemelmans, Gustavo Turecki, Naguib Mechawar, Jonathan A Javitch, Jocelyne Caboche, Pierre Trifilieff, Jacques Barik, Peter Vanhoutte

PMID34669474

ABSTRACT

[Figure: see text].

MATERIALS

Product Number

Brand

Product Description

05-432

Sigma-Aldrich

Anti-NR1 Antibody, CT, Upstate^®, from mouse

MAB5782

Sigma-Aldrich

Anti-NMDAR2B Antibody, NT, ascites fluid, clone 1A8.9B3, Chemicon^®

ABN462

Sigma-Aldrich

Anti-Dopamine D2 Receptor Antibody, from rabbit, purified by affinity chromatography

D2944

Sigma-Aldrich

Anti-D₁ Dopamine Receptor antibody,Rat monoclonal, clone 1-1-F11 s.E6, purified from hybridoma cell culture