- Double nucleophilic attack on isocyanide carbon: a synthetic strategy for 7-aza-tetrahydroindoles.
Double nucleophilic attack on isocyanide carbon: a synthetic strategy for 7-aza-tetrahydroindoles.
Chemical communications (Cambridge, England) (2012-11-13)
Yifei Li, Xianxiu Xu, Chunyu Xia, Lingjuan Zhang, Ling Pan, Qun Liu
PMID23145430
ABSTRACT
A novel and efficient route for the synthesis of 7-aza-tetrahydroindoles from N-aryl/alkyl-alkenoylacetamides and ethyl isocyanoacetate is described. A mechanism, involving a stepwise [3+2] cycloaddition-intramolecular aza-Michael addition cascade, is proposed that explains the origin of the double nucleophilic attack on the isocyanide carbon atom.
MATERIALS
Product Number
Brand
Product Description
SKU
Pack Size
Availability
Price
Quantity