D7400

2′-Deoxyadenosine monohydrate

≥99%

• Synonym(s): 9-(2-Deoxy-β-D-ribofuranosyl)adenine, Adenine deoxyriboside
• Empirical Formula (Hill Notation): C₁₀H₁₃N₅O₃ · H₂O
• CAS Number: 16373-93-6
• Molecular Weight: 269.26
• Beilstein: 91015
• EC Number: 213-488-7
• MDL number: MFCD00005754
• UNSPSC Code: 41106305
• PubChem Substance ID: 24894129
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Assay: ≥99%
• form: powder
• solubility: water: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: [H]O[H].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3
• InChI: 1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
• InChI key: OLXZPDWKRNYJJZ-RRKCRQDMSA-N

Description

Application

2′-Deoxyadenosine monohydrate has been used:

• as a component for nucleoside supplementation
• as a standard for to estimate DNA global methylation rate in proliferating oil palm embryogenic suspensions
• to reverse sterile alpha motif (SAM) and histidine-aspartate (HD) domain-containing protein (SAMHD1)
• inhibition of human immunodeficiency virus (HIV-1) and hepatitis B virus (HBV)

Biochem/physiol Actions

2′-Deoxyadenosine (2′-dAdo), a deoxyribonucleoside, may be used by some cells as an energy source under energy stress conditions and to affect cAMP levels. 2′-dAdo is used in comparison studies of the functions of adenosine analogues on various biological processes.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves