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Key Documents

D9885

Sigma-Aldrich

DEAE-Dextran hydrochloride

powder

Synonym(s):

Diethylaminoethyl-dextran hydrochloride

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About This Item

CAS Number:
9064-91-9
MDL number:
MFCD00081561
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

bacterial (Leuconostoc mesenteroides)

form

powder

extent of labeling

~3.2% nitrogen

useful pH range

4.0 - 6.0

solubility

H2O: soluble 100 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

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Application

DEAE-Dextran 500, a polycationic stabilizing molecule and transfection reagent, is used in the development of sustained release protein delivery and nucleic acid transfection systems. DEAE-Dextran 500 may be used for cell immobilization in biosensors.

Preparation Note

Prepared from dextran of average mol. wt. 500,000

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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DEAE-dextran transfection of mammalian cultured cells.
E T Schenborn et al.
Methods in molecular biology (Clifton, N.J.), 130, 147-153 (1999-12-10)
Transfection using DEAE-dextran.
Selden RF.
Current Protocols in Immunology, 10, 10-10 (2001)
Nattamon Niyomdecha et al.
Heliyon, 6(6), e04050-e04050 (2020-06-13)
Niclosamide has been known to inhibit a number of pH-dependent viruses via the neutralization of endosomal acidic pH. It has also been shown to disrupt the mTORC1 signaling pathway. The replication of many viruses requires mTORC1 activation. Here, we investigated
Shingo Kikuchi et al.
International journal of pharmaceutics, 386(1-2), 149-155 (2009-11-20)
A multivariate statistical technique was applied to designing a tablet for the sustained release over 24h of diltiazem hydrochloride, a model highly water-soluble drug. Tablets of a hydrophilic matrix composed of dextran derivatives and hypromellose were prepared. The formulations were
Bhawna Yadav et al.
Cell surface (Amsterdam, Netherlands), 6, 100042-100042 (2020-12-29)
We designed experiments to assess whether fungal cell wall mannans function as an immune shield or an immune agonist. Fungal cell wall β-(1,3)-glucan normally plays a major and dominant role in immune activation. The outer mannan layer has been variously
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Related Content

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

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