SAB4502987
Anti-TSG6 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
α-induced protein 6, TSG6, tumor necrosis factor
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 31 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TSG6(7130)
General description
Anti-TSG6 Antibody detects endogenous levels of total TSG6 protein.
Tumor necrosis factor (TNF)-α–stimulated gene 6 protein (TSG-6) is an inflammation-associated secreted protein. It has a molecular weight of about 35 kDa. TSG-6 possesses Link and CUB_C domains, along with a with a short amino-terminal sequence. The gene encoding this protein is localized on human chromosome 2q23.3.
Immunogen
The antiserum was produced against synthesized peptide derived from human TSG6.
Immunogen Range: 21-70
Immunogen Range: 21-70
Biochem/physiol Actions
Tumor necrosis factor (TNF)-α–stimulated gene 6 protein (TSG-6) has been implicated in regulation of cell-cell and cell-matrix interactions during inflammation and tumorigenesis. TSG-6 possesses anti-inflammatory properties. It is also known to reduce inflammatory reactions triggered by ischemia in the heart. Thus, it might have a potential role in treating heart disease with other cells such as skeletal myoblasts, fetal myoblasts and embryonic stem cells.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
Choi H, et al.
Blood (2011)
A Novel Allelic Variant of the Human TSG-6 Gene Encoding an Amino Acid Difference in the CUB Module CHROMOSOMAL LOCALIZATION, FREQUENCY ANALYSIS, MODELING, AND EXPRESSION.
Nentwich HA, et al.
The Journal of Biological Chemistry, 277(18), 15354-15362 (2002)
The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine/glycosaminoglycan interactions.
Dyer DP, et al.
The Journal of Biological Chemistry (2016)
Krishna Prahlad Maremanda et al.
Toxicology and applied pharmacology, 385, 114788-114788 (2019-11-05)
Cigarette smoke (CS)-induced lung inflammation and Chronic Obstructive Pulmonary disease (COPD) involves mitochondrial dysfunction. Mesenchymal stem cells (MSC) and MSC-derived exosomes (EXO) are reported to show therapeutic effects in many animal models of inflammation and injury. In the present study
Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6.
Ryang H L, et al.
Cell Stem Cell, 5(1), 54-63 (2009)
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