Skip to Content
Merck
  • seco-Abietane diterpenoids, a phenylethanoid derivative, and antitubercular constituents from Callicarpa pilosissima.

seco-Abietane diterpenoids, a phenylethanoid derivative, and antitubercular constituents from Callicarpa pilosissima.

Journal of natural products (2009-02-06)
Jih-Jung Chen, Hung-Ming Wu, Chien-Fang Peng, Ih-Sheng Chen, Shih-Der Chu
ABSTRACT

Six new compounds, including five new seco-abietane diterpenoids, 12-deoxy-seco-hinokiol methyl ester (1), 12-deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid A (3), 9alpha-hydroxycallicarpic acid A (4), and callicarpic acid B (5), and a new phenylethanoid derivative, 4-hydroxyphenethyl tetradecanoate (6), have been isolated from the leaves and twigs of Callicarpa pilosissima, together with 14 known compounds (7-20). The structures of these new compounds were determined through analyses of physical data. 12-Deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid B (5), and alpha-tocopherol trimer B (15) exhibit antitubercular activities (MICs <or= 63.6 microM) against Mycobacterium tuberculosis H(37)Rv in vitro.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Stearic acid 50, tested according to Ph. Eur.
Sigma-Aldrich
Stearic acid, Grade I, ≥98.5% (capillary GC)
Sigma-Aldrich
Squalene, ≥98%, liquid
Sigma-Aldrich
Stearic acid, reagent grade, 95%
Supelco
Stearic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Supelco
Stearic acid, analytical standard
Sigma-Aldrich
Stearic acid, ≥95%, FCC, FG