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Merck

Anticonvulsant hypersensitivity syndrome (AHS): a case report.

Tennessee medicine : journal of the Tennessee Medical Association (2013-04-27)
Bradley R Keel, Catherine L Payne
ABSTRACT

Anticonvulsant Hypersensitivity Syndrome (AHS) is a rare complication of common drugs used today. It is unusual in that it occurs later than most other drug reactions, about two to six weeks after initiation of the offending agent. It also has a hereditary background unlike most other drug reactions. This reaction is caused by the aromatic amines and causes hepatitis, skin rash, fever, and other systemic organ involvement can occur. The reaction is rare but often fatal, thus the observer should be acutely aware of this in the months following initiation of the agents.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
5,5-Diphenylhydantoin, ≥98%
Phenytoin, European Pharmacopoeia (EP) Reference Standard
Supelco
Phenytoin, Pharmaceutical Secondary Standard; Certified Reference Material
Phenytoin for system suitability, European Pharmacopoeia (EP) Reference Standard
Supelco
Phenytoin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®