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479675

Sigma-Aldrich

N-(tert-Butyl)hydroxylamine acetate

97%

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About This Item

Linear Formula:
(CH3)3CNHOH·CH3CO2H
CAS Number:
253605-31-1
Molecular Weight:
149.19
MDL number:
MFCD01321354
UNSPSC Code:
12352100
PubChem Substance ID:
24871640
NACRES:
NA.22

Assay

97%

mp

65-69 °C (lit.)

SMILES string

CC(O)=O.CC(C)(C)NO

InChI

1S/C4H11NO.C2H4O2/c1-4(2,3)5-6;1-2(3)4/h5-6H,1-3H3;1H3,(H,3,4)

InChI key

QGYZLVSWEOXOFT-UHFFFAOYSA-N

General description

N-(tert-Butyl)hydroxylamine acetate (NtBuHA acetate) is a derivative of hydroxylamine that shows thioesterase-mimetic and antioxidant characteristics.

Application

N-(tert-Butyl)hydroxylamine acetate has been used in a study to understand its effect on CD (cathepsin D) activity.
It may be used in the preparation of:
  • (Z)-α-5-bromo-N-tert-butyl-2-methoxyphenylnitrone
  • ONO-type pincer ligand
  • hydroxyphenyl nitrones

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Advanced Synthesis & Catalysis, 352(10), 1779-1783 (2010)
(Z)-α-5-Bromo-N-tert-butyl-2-methoxyphenylnitrone.
Guo H, et al.
Acta Crystallographica Section E, Structure Reports Online, 63(10), 3943-3943 (2007)
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.
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European Journal of Medicinal Chemistry, 58, 44-49 (2012)
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Neurodegeneration is a devastating manifestation in the majority of >50 lysosomal storage disorders (LSDs). Neuronal ceroid lipofuscinoses (NCLs) are the most common childhood neurodegenerative LSDs. Mutations in 13 different genes (called CLNs) underlie various types of NCLs, of which the
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Journal of inherited metabolic disease, 43(5), 1082-1101 (2020-04-13)
Infantile neuronal ceroid lipofuscinosis (INCL) is a devastating neurodegenerative lysosomal storage disease (LSD) caused by inactivating mutations in the CLN1 gene. CLN1 encodes palmitoyl-protein thioesterase-1 (PPT1), a lysosomal enzyme that catalyzes the deacylation of S-palmitoylated proteins to facilitate their degradation

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