840046X

Brain PI(4,5)P2

Avanti Research^™ - A Croda Brand

• Synonym(s): Brain PI(4,5)P2, L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt), chloroform:methanol:water (20:9:1)
• CAS Number: 383907-42-4
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: liquid
• packaging: pkg of 1 × 1 mL (840046X-10mg); pkg of 1 × 1 mL (840046X-1mg); pkg of 1 × 1 mL (840046X-5mg); pkg of 1 × 2.5 mL (840046X-25mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• concentration: 1 mg/mL (840046X-1mg); 10 mg/mL (840046X-10mg); 10 mg/mL (840046X-25mg); 5 mg/mL (840046X-5mg)
• lipid type: phosphoglycerides
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@H]1O)([O-])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]
• InChI: 1S/C47H85O19P3.3H3N/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)63-39(37-61-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-62-69(59,60)66-45-42(50)43(51)46(64-67(53,54)55)47(44(45)52)65-68(56,57)58;;;/h11,13,17,19,22,24,28,30,39,42-47,50-52H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,59,60)(H2,53,54,55)(H2,56,57,58);3*1H3/b13-11-,19-17-,24-22-,30-28-;;;/t39-,42?,43+,44?,45-,46?,47?;;;/m1.../s1
• InChI key: GAIOWTITBYPFJE-JVILRMJCSA-N

Description

General description

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.

Phosphatidyl inositol (4,5) bisphosphate (PI(4,5)P₂)/PIP₂ is produced from phosphatidyl inositol monophosphates (PIP).

Application

Brain PI(4,5)P₂ has been used in the preparation of liposomes for dynamin-catalyzed fission assay and as a constituent in the lipid mixture for dual polarisation interferometry(DPI)

Biochem/physiol Actions

Phosphatidyl inositol (4,5) bisphosphate (PI(4,5)P₂) plays a key role in the early stages of vesicle formation. It functions in the recruitment of endocytic coats by binding to variety of proteins involved in endocytic trafficking. PI(4,5)P₂ is hydrolysed by phospholipase C to yield the signaling molecules diacylglycerol (DAG) and phosphatidyl inositol (3,4,5) triphosphate (PI(3,4,5)P₃). PI(4,5)P₂ is required for the functioning of many ion channels.

Packaging

5 mL Clear Glass Sealed Ampule (840046X-10mg)

5 mL Clear Glass Sealed Ampule (840046X-1mg)

5 mL Clear Glass Sealed Ampule (840046X-25mg)

5 mL Clear Glass Sealed Ampule (840046X-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H331,H312,H315,H319,H336,H351,H361d,H370,H372
• Precautionary Statements: P210 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3
• Target Organs: Central nervous system, Eyes,Central nervous system, Liver,Kidney
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3