T-038

(+)-11-Nor-Δ⁹-THC-9-carboxylic acid glucuronide solution

100 μg/mL in methanol, ampule of 1 mL, Cerilliant^®

• Empirical Formula (Hill Notation): C₂₇H₃₆O₁₀
• CAS Number: 1362113-32-3
• Molecular Weight: 520.57
• EC Number: 200-659-6
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): cannabis testing; forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• SMILES string: CCCCCc1cc(O)c2C3C=C(CCC3C(C)(C)Oc2c1)C(=O)OC4OC(C(O)C(O)C4O)C(O)=O
• InChI: 1S/C27H36O10/c1-4-5-6-7-13-10-17(28)19-15-12-14(8-9-16(15)27(2,3)37-18(19)11-13)25(34)36-26-22(31)20(29)21(30)23(35-26)24(32)33/h10-12,15-16,20-23,26,28-31H,4-9H2,1-3H3,(H,32,33)
• InChI key: UWXZAZRSQQLWKH-UHFFFAOYSA-N

Description

General description

11-Nor-Δ⁹-THC-9-carboxylic acid glucuronide is the phase II metabolite of the phytocannabinoid ∆⁹-tetrahydrocannabinol (THC). This certified Snap-N-Spike^® reference solution is suitable for numerous GC/MS or LC/MS applications from pharmaceutical testing and research to clinical toxicology or forensic analysis. This Certified Reference Material provides added value in allowing calibration of THC acid glucuronide by LC-MS/MS methods without the need for an added hydrolysis step.

Application

The Certified Spiking Solution^® is suitable for (+)-11-Nor-Δ⁹-THC-9-carboxylic acid glucuronide testing by HPLC, GC/MS, or LC-MS/MS methods in forensic analysis, clinical toxicology, urine drug testing, and Cannabis potency or impurity profiling testing applications. The Certified Reference Material (CRM) in solution can also be used as follows:

• Development of an automated sample preparation method based on solid phase extraction (SPE) to determine ∆⁹-tetrahydrocannabinol (THC) and its three primary metabolites in a variety of matrices, such as serum, saliva, and urine using liquid chromatography-mass spectrometry (LC-MS)
• Liquid chromatographic-tandem mass spectrometric (LC-MS/MS) determination of cannabinoids and their metabolites in whole blood samples
• Detection and quantification of 11-Nor-∆⁹-tetrahydrocannabinol-9-carboxylic acid glucuronide (THC-COOH-glu) in hair samples by ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)
• Simultaneous residue analysis of phytocannabinoids, their metabolites, and amphetamine-type stimulants (ATS) in 11 hair samples obtained from drug users by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
• Determination of measurement uncertainty in the quantitative analysis of 11-nor-∆⁹-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) and its glucuronide analogue (THC-COOH-glu) from urine samples by using LC-MS/MS

Features and Benefits

• Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
• Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
• Rigorously tested through real-time stability studies to ensure accuracy and shelf life
• Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
• Flame sealed under argon into ampoules for long-term shelf life
• Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Other Notes

Not to be used for immunoassay

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup