46648

Praziquantel

VETRANAL^®, analytical standard

• Synonym(s): 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
• Empirical Formula (Hill Notation): C₁₉H₂₄N₂O₂
• CAS Number: 55268-74-1
• Molecular Weight: 312.41
• Beilstein: 761557
• EC Number: 259-559-6
• MDL number: MFCD00058531
• UNSPSC Code: 41116107
• PubChem Substance ID: 329756613
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 200
• product line: VETRANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• antibiotic activity spectrum: parasites
• application(s): clinical testing
• format: neat
• Mode of action: cell membrane | interferes
• storage temp.: 2-8°C
• SMILES string: O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4
• InChI: 1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
• InChI key: FSVJFNAIGNNGKK-UHFFFAOYSA-N

Description

General description

Chemical structure: quinolone

Praziquantel (PZQ) is a pyrazino-isoquinoline compound used as a broad-spectrum anthelmintic drug against trematode and cestode infections.

Application

PZQ may be used as a reference standard for the determination for PZQ in:

• Surface water samples by solid phase extraction (SPE) and ultra-high performance liquid chromatography-quadrupole linear ion trap tandem mass spectrometry (UHPLC-QqLIT-MS) equipped with electrospray ionization (ESI) source.
• Plants by HPLC with triple quadrupole mass spectrometry (HPLC-ESI-QqQ-MS/MS) operating in multiple reaction monitoring (MRM) mode.
• Tablet formulations by reversed phase (RP) HPLC with ultraviolet (UV) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Hazard Statements: H412
• Precautionary Statements: P273 - P501
• Hazard Classifications: Aquatic Chronic 3
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves