- A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
Organic letters (2014-06-17)
Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li
PMID24933098
ABSTRACT
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
MATERIALS
Product Number
Brand
Product Description
Copper - O.F.H.C., rod, 50mm, diameter 50.0mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 100mm, outside diameter 4.0mm, inside diameter 3mm, wall thickness 0.5mm, 99.95+%
Copper - O.F.H.C., sheet, 100x100mm, thickness 6.35mm, 99.95+%
Copper - O.F.H.C., rod, 100mm, diameter 25.4mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 500mm, outside diameter 8.0mm, inside diameter 6mm, wall thickness 1.0mm, 99.95+%
Copper - O.F.H.C., wire reel, 50m, diameter 0.125mm, annealed, 99.95+%
Copper - O.F.H.C., tube, 100mm, outside diameter 6.0mm, inside diameter 4mm, wall thickness 1.0mm, 99.95+%
Copper - O.F.H.C., tube, 1000mm, outside diameter 0.635mm, inside diameter 0.275mm, wall thickness 0.18mm, 99.95+%
Copper - O.F.H.C., tube, 500mm, outside diameter 1.23mm, inside diameter 0.51mm, wall thickness 0.36mm, 99.95+%
Copper - O.F.H.C., tube, 500mm, outside diameter 9.5mm, inside diameter 7.9mm, wall thickness 0.8mm, 99.95+%
Copper - O.F.H.C., wire reel, 2m, diameter 2.5mm, hard, 99.95+%
Copper - O.F.H.C., foil, light tested, 150x150mm, thickness 0.010mm, hard, 99.95+%
Copper - O.F.H.C., wire reel, 50m, diameter 0.25mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 200mm, outside diameter 2.54mm, inside diameter 1.54mm, wall thickness 0.5mm, 99.95+%
Copper - O.F.H.C., wire reel, 10m, diameter 2.5mm, hard, 99.95+%
Copper - O.F.H.C., wire reel, 10m, diameter 0.80mm, as drawn, 99.95+%
Copper - O.F.H.C., wire reel, 20m, diameter 1.0mm, as drawn, 99.95+%
Copper - O.F.H.C., sheet, 50x50mm, thickness 6.35mm, 99.95+%
Copper - O.F.H.C., wire reel, 50m, diameter 0.75mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 200mm, outside diameter 10mm, inside diameter 8mm, wall thickness 1.0mm, 99.95+%
Copper - O.F.H.C., tube, 1000mm, outside diameter 6.0mm, inside diameter 4mm, wall thickness 1.0mm, 99.95+%
Copper - O.F.H.C., tube, 1000mm, outside diameter 9.5mm, inside diameter 7.9mm, wall thickness 0.8mm, 99.95+%
Copper - O.F.H.C., sheet, 150x150mm, thickness 12.7mm, 99.99+%
Copper - O.F.H.C., tube, 500mm, outside diameter 2.54mm, inside diameter 1.54mm, wall thickness 0.5mm, 99.95+%
Copper - O.F.H.C., wire reel, 20m, diameter 1.5mm, hard, 99.95+%
Copper - O.F.H.C., wire reel, 50m, diameter 0.80mm, as drawn, 99.95+%
Copper - O.F.H.C., foil, 150x150mm, thickness 1.0mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 25x25mm, thickness 0.20mm, hard, 99.95+%
Copper - O.F.H.C., foil, 100x100mm, thickness 0.1mm, hard, 99.95+%
Copper - O.F.H.C., wire reel, 5m, diameter 0.75mm, as drawn, 99.95+%