412422

PAMAM dendrimer, ethylenediamine core, generation 3.0 solution

20 wt. % in methanol

• Synonym(s): Starburst PAMAM-G 3
• Linear Formula: [NH₂(CH₂)₂NH₂]:(G=3);dendri PAMAM(NH₂)₃₂
• CAS Number: 153891-46-4
• Molecular Weight: 6908.84
• MDL number: MFCD00197936
• UNSPSC Code: 12162002
• NACRES: NA.23

Properties

• description: amino surface groups
• form: liquid
• mol wt: generation 3.0
• feature: core type ethylenediamine core (2-carbon core)
• concentration: 20 wt. % in methanol
• no. Surface Groups: 32
• refractive index: n20/D 1.367
• bp: 64.7 °C
• density: 0.863 g/mL at 25 °C
• storage temp.: 2-8°C

Description

General description

PAMAM dendrimer is a symmetrical polymer with a large number of terminal groups that can easily bind to biomolecules due to their biocompatibility and affinity. These dendrimers have a multivalent surface that contains envelopes and various active sites at the core with the attached dendrons. They are highly branched nanoscale polymers that are extensively used in the field of biomedicine for targeted drug delivery.

Application

PAMAM dendrimers can be used as transfection agents for the delivery of nucleic acids. For example, it can be used in the pulmonary delivery of siRNA directed against tumor necrosis factor (TNF).

Physical form

Contains 32 surface primary amino groups

Legal Information

Manufactured by Dendritech^®, Inc.

Dendritech is a registered trademark of Dendritech, Inc.

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes,Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 51.8 °F - closed cup
• Flash Point(C): 11 °C - closed cup