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489350

Sigma-Aldrich

L-(–)-Norepinephrine-(+)-bitartrate

α,β-Adrenergic agonist.

Synonym(s):

L-(−)-Norepinephrine-(+)-bitartrate salt monohydrate, R(–)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol-(+)-tartrate, Noradrenaline

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · C4H6O6 · H2O
CAS Number:
108341-18-0
Molecular Weight:
337.28
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥97% (LC/MS)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1

InChI key

LNBCGLZYLJMGKP-LUDZCAPTSA-N

General description

α,β-Adrenergic agonist. A vasoconstrictive agent that causes down-regulation of angiotensin II receptors.
α,β-Adrenergic agonist. A vasoconstrictive agent that causes down-regulation of angiotensin II receptors. Oxidation sensitive.

Biochem/physiol Actions

Cell permeable: no
Primary Target
α,β-Adrenergic agonist
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Preparation Note

Addition of sodium bisulfite (at a final concentration of 0.1%) is necessary to prevent oxidation.

Reconstitution

Following reconstituiton, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Yang, H., et al. 1996. Hypertension 27, 1277.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H Yang et al.
Hypertension (Dallas, Tex. : 1979), 27(6), 1277-1283 (1996-06-01)
Norepinephrine causes downregulation of angiotensin II (Ang II) receptors in Wistar-Kyoto rat (WKY) brain neuronal cultures. The aim of this study was to compare the cross talk between Ang II and alpha1-adrenergic receptors in these neuronal cultures. Norepinephrine causes a
Inbal Rachmin et al.
Experimental dermatology, 30(4), 578-587 (2021-02-19)
Hair greying depends on the altered presence and functionality of hair follicle melanocytes. Melanocyte stem cells (MelSCs) reside in the bulge of hair follicles and give rise to migrating and differentiating progeny during the anagen phase. Ageing, genotoxic stress, redox

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