Skip to Content
Merck
  • A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction.

A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction.

Organic & biomolecular chemistry (2013-03-15)
Meng Wang, Cun Tan, Qian He, Yuyuan Xie, Chunhao Yang
PMID23487245
ABSTRACT

A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.

MATERIALS
Product Number
Brand
Product Description
P50803
Sigma-Aldrich
Propargyl alcohol, 99%
686468
Sigma-Aldrich
Palladium, nanopowder, <25 nm particle size (TEM), ≥99.5%
373206
Sigma-Aldrich
Palladium, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.95% trace metals basis
203998
Sigma-Aldrich
Palladium, powder or granules, 99.99% trace metals basis
464651
Sigma-Aldrich
Palladium, powder, <75 μm, 99.9% trace metals basis
348694
Sigma-Aldrich
Palladium, wire, diam. 0.5 mm, 99.9% trace metals basis
348678
Sigma-Aldrich
Palladium, foil, thickness 1.0 mm, 99.9% trace metals basis
348643
Sigma-Aldrich
Palladium, foil, thickness 0.25 mm, 99.98% trace metals basis
267082
Sigma-Aldrich
Palladium, sponge, 99.9% trace metals basis
267120
Sigma-Aldrich
Palladium, foil, thickness 0.025 mm, 99.9% trace metals basis
267112
Sigma-Aldrich
Palladium, wire, diam. 1.0 mm, 99.9% trace metals basis
326666
Sigma-Aldrich
Palladium, powder, <1 μm, ≥99.9% trace metals basis
287474
Sigma-Aldrich
Palladium, foil, thickness 0.5 mm, 99.9% trace metals basis
203939
Sigma-Aldrich
Palladium, powder, 99.995% trace metals basis