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  • Cholesterol-lowering effect of rice bran protein containing bile acid-binding proteins.

Cholesterol-lowering effect of rice bran protein containing bile acid-binding proteins.

Bioscience, biotechnology, and biochemistry (2014-11-07)
Jilite Wang, Masaya Shimada, Yukina Kato, Mio Kusada, Satoshi Nagaoka
ABSTRACT

Dietary plant protein is well known to reduce serum cholesterol levels. Rice bran is a by-product of rice milling and is a good source of protein. The present study examined whether feeding rats a high-cholesterol diet containing 10% rice bran protein (RBP) for 10 d affected cholesterol metabolism. Rats fed dietary RBP had lower serum total cholesterol levels and increased excretion of fecal steroids, such as cholesterol and bile acids, than those fed dietary casein. In vitro assays showed that RBP strongly bound to taurocholate, and inhibited the micellar solubility of cholesterol, compared with casein. Moreover, the bile acid-binding proteins of the RBP were eluted by a chromatographic column conjugated with cholic acid, and one of them was identified as hypothetical protein OsJ_13801 (NCBI accession No. EAZ29742) using MALDI-TOF mass spectrometry analysis. These results suggest that the hypocholesterolemic action of the RBP may be caused by the bile acid-binding proteins.

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Supelco
Cholesterol solution, certified reference material, 10 mg/mL in chloroform
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1 mL
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Sigma-Aldrich
Cholic acid, from bovine and/or ovine, ≥98%
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$472.00
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Cholesterol, powder, BioReagent, suitable for cell culture, ≥99%
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$472.00
0.5 mL
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1 mL
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Sigma-Aldrich
Cholesterol, from sheep wool, ≥92.5% (GC), powder
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$472.00
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$617.00
1 mL
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$953.00
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Cholesterol, Sigma Grade, ≥99%
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$472.00
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1 mL
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1-Oleoyl-rac-glycerol, ≥99%
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$472.00
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1-Oleoyl-rac-glycerol, technical, ~40% (TLC)
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Cholesterol, tested according to Ph. Eur.
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Cholesterol, Pharmaceutical Secondary Standard; Certified Reference Material
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Cholic acid, European Pharmacopoeia (EP) Reference Standard
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Cholesterol, from sheep wool, Controlled origin, meets USP/NF testing specifications
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SyntheChol® NS0 Supplement, 500 ×, synthetic cholesterol, animal component-free, aqueous solution, sterile-filtered, suitable for cell culture
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Sodium cholate hydrate, suitable for cell culture, BioReagent
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Sodium cholate hydrate, BioXtra, ≥99%
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Oleic acid, BioReagent, suitable for cell culture
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Oleic acid, meets analytical specification of Ph, Eur., 65.0-88.0% (GC)
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Oleic acid, analytical standard
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Sodium cholate hydrate, ≥97.0% (dried material, NT)
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Oleic acid, ≥99% (GC)
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Sodium cholate hydrate, from bovine and/or ovine bile, ≥99%
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Supelco
Oleic acid, Selectophore, ≥99%
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Cholesterol, Plant-Derived, SyntheChol®
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Oleic acid, technical grade, 90%
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Oleic acid, natural, FCC
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Sodium cholate hydrate
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Oleic acid, European Pharmacopoeia (EP) Reference Standard
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USP
Glyceryl monooleate, 90%, United States Pharmacopeia (USP) Reference Standard
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