추천 제품
분석
99%
mp
220-223 °C (lit.)
SMILES string
OC1CN2CC[C@H]1CC2
InChI
1S/C7H13NO/c9-7-5-8-3-1-6(7)2-4-8/h6-7,9H,1-5H2
InChI key
IVLICPVPXWEGCA-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
(R)-3-Quinuclidinol is a valuable compound for the production of various pharmaceuticals.
애플리케이션
3-Quinuclidinol has been used:
- as chiral building block for many antimuscarinic agents
- in chemoselective α−iodination of various simple and multi-functionalised acrylic esters via Morita-Baylis-Hillman protocol
- as reagent for cleavage of β-keto and vinylogous β-keto esters
- as synthon for the preparation of cholinergic receptor ligands and anesthetics
- as catalyst for condensation of methyl vinyl ketone with aldehydes
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Journal of medicinal chemistry, 34(10), 2989-2993 (1991-10-01)
Seven analogues of 3-quinuclidinyl benzilate (QNB) in which one phenyl ring was replaced by an alkoxyalkyl moiety were synthesized and their affinities for the muscarinic cholinergic receptor determined. An oxygen in the beta-position of the moiety was not well-tolerated. By
Tetrahedron Letters, 31, 4509-4509 (1990)
Khim.-Farm. Zh., 26, 12-12 (1992)
Organic letters, 15(19), 4917-4919 (2013-09-21)
A new keto reductase (ArQR), identified from Agrobacterium radiobacter ECU2556, can efficiently reduce 3-quinuclidinone in excellent enantioselectivity and high space-time yield for the synthesis of (R)-3-quinuclidinol, a chiral building block of many antimuscarinic agents. This is the first time that
Selective Cleavage of ?-Keto and Vinylogous ?-Keto Esters by 3-Quinuclidinol.
Synthetic Communications, 5(5), 341-345 (1975)
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