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Merck
모든 사진(2)

문서

383449

Sigma-Aldrich

3-Formylchromone

97%

동의어(들):

4-Oxo-4H-1-benzopyran-3-carboxaldehyde

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About This Item

실험식(Hill 표기법):
C10H6O3
CAS Number:
Molecular Weight:
174.15
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22

분석

97%

형태

solid

mp

151-153 °C (lit.)

SMILES string

O=CC1=COc2ccccc2C1=O

InChI

1S/C10H6O3/c11-5-7-6-13-9-4-2-1-3-8(9)10(7)12/h1-6H

InChI key

FSMYWBQIMDSGQP-UHFFFAOYSA-N

유전자 정보

human ... PTPN1(5770)

일반 설명

Electrospray ionization mass spectrometry (ESI-MS) of protonated 3-formylchromone (3-FC) shows loss of H2 as a major fragmentation route to yield a ketene cation, which on reaction with water forms a protonated carboxylic acid. The invivo salubrious effects of 3-FC against nitrosodiethylamine (NDEA) mediated early hepatocellular carcinogenesis has been investigated. Synthesis and characterization of 3-FC and its derivatives has been reported.

애플리케이션

3-Formylchromone may be used in the following studies:
  • Preparation of library of novel (E)-3-(2-arylcarbonyl-3-(arylamino)allyl)-4H-chromen-4-ones, by three-component domino reactions with (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones and anilines under catalyst-free conditions.
  • Facile and ecofriendly synthesis of new chromonyl chalcones.
  • Synthesis of 3-(2-hydroxybenzoyl)quinolines and 7H-chromeno[3,2-c]quinolin-7-ones.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

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1 of 1

Andrey S Plaskon et al.
The Journal of organic chemistry, 73(15), 6010-6013 (2008-07-03)
A facile and versatile procedure for the synthesis of 3-(2-hydroxybenzoyl)quinolines and 7H-chromeno[3,2-c]quinolin-7-ones was elaborated on the basis of TMSCl-mediated recyclization of 3-formylchromone with various anilines. Limitations and scope of this methodology were established, and a possible mechanism for the heterocyclizations
Pitchaimani Prasanna et al.
Beilstein journal of organic chemistry, 10, 459-465 (2014-03-13)
The three-component domino reactions of (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones, 3-formylchromone and anilines under catalyst-free conditions afforded a library of novel (E)-3-(2-arylcarbonyl-3-(arylamino)allyl)-4H-chromen-4-ones in good to excellent yields and in a diastereoselective transformation. This transformation generates one C-C and one C-N bond and presumably proceeds
Zeba N Siddiqui et al.
Journal of enzyme inhibition and medicinal chemistry, 27(1), 84-91 (2011-05-27)
A facile and ecofriendly synthesis of new chromonyl chalcones 3a-b from 3-formylchromone 1 and active methyl compounds 2a-b is reported under thermal solvent-free heating condition in good yields. The chromonyl chalcones 3a-b were used as intermediates under green condition for
Muhammed Bilaal Ismail et al.
Nucleosides, nucleotides & nucleic acids, 38(12), 950-971 (2019-07-11)
Herein, we report the DNA interaction studies of rhenium(I) and -(V) compounds with Schiff base chelates encompassing biologically relevant moieties. More specifically, the DNA interaction capabilities of these rhenium complexes were probed using Gel Electrophoresis and Calf Thymus-DNA titrations monitored
Koichi Takao et al.
Bioorganic chemistry, 83, 432-437 (2018-11-15)
A series of eighteen pyrano[4,3-b][1]benzopyranone derivatives (1a-9b) were synthesized, and structure-activity relationships of their monoamine oxidase (MAO) A and B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activities were evaluated. Most of the synthesized compounds exhibited weak inhibitory activity toward MAO-A

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