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Merck
모든 사진(1)

Key Documents

807761

Sigma-Aldrich

palmitic-acid-5-hydroxy-stearic-acid

95%

동의어(들):

5-PAHSA

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About This Item

실험식(Hill 표기법):
C34H66O4
CAS Number:
Molecular Weight:
538.89
UNSPSC 코드:
12352106
NACRES:
NA.22

Quality Level

분석

95%

형태

powder

mp

39 °C

저장 온도

2-8°C

일반 설명

Palmitic-acid-5-hydroxy-stearic-acid (5-PAHSA) is also referred to as 5-hexadecanoyloxyoctadecanoic acid (IUPAC name).

애플리케이션

5-PAHSA is composed of palmitic acid attached to stearic acid and is in the class of branched lipids referred to as fatty acid esters of hydroxy fatty acids (FAHFAs). 5-PAHSA was found at reduced levels in adipose tissue and serum of insulin-resistant mice. Levels were also found to be lower in white adipose tissue and serum of humans. Studies of oral administration of 5-PAHSA to obese, diabetic mice showed improved glucose tolerance. In characterizing the mechanism, it was found that 5-PAHSA stimulates insulin and GLP-1 secretion and also enhances glucose transport and the Glut4 transporter through activation of GPR-120.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Mark M Yore et al.
Cell, 159(2), 318-332 (2014-10-11)
Increased adipose tissue lipogenesis is associated with enhanced insulin sensitivity. Mice overexpressing the Glut4 glucose transporter in adipocytes have elevated lipogenesis and increased glucose tolerance despite being obese with elevated circulating fatty acids. Lipidomic analysis of adipose tissue revealed the

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