H47003

5-Hydroxy-1,4-naphthoquinone

97%

• 동의어(들): Juglone
• 실험식(Hill 표기법): C₁₀H₆O₃
• CAS Number: 481-39-0
• Molecular Weight: 174.15
• Beilstein: 1909764
• EC Number: 207-567-5
• MDL number: MFCD00001684
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24895654
• NACRES: NA.22

속성

• 분석: 97%
• mp: 161-163 °C (lit.)
• SMILES string: Oc1cccc2C(=O)C=CC(=O)c12
• InChI: 1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H
• InChI key: KQPYUDDGWXQXHS-UHFFFAOYSA-N

설명

애플리케이션

5-Hydroxy-1,4-naphthoquinone (juglone) can be used as a starting material for the synthesis of:

• Trypanocidal drugs.[1]
• Tacrine-naphthoquinone hybrids with potential application in the treatment of Alzheimer′s disease.[2]
• Juglone-based electroactive polymer, poly(5-hydroxy-1,4-naphthoquinone-co-5-hydroxy-3-thioacetic acid-1,4-naphthoquinone), for the electrochemical detection of DNA hybridization.[3]
• Ent-nocardione A, naturally-occurring tyrosine phosphatase inhibitor.[4]

Juglone can also be used as a dienophile in the Diels–Alder reaction for the synthesis of variety of C-aryl glycosides.[5]

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges