QBD10551

MAL-dPEG^®₄-TFP ester

• 동의어(들): Polyethylene glycol
• 실험식(Hill 표기법): C₂₄H₂₈F₄N₂O₉
• Molecular Weight: 564.48
• MDL number: MFCD28505515
• UNSPSC 코드: 12352108
• PubChem Substance ID: 329823940
• NACRES: NA.22

속성

• 분석: >90%
• 형태: solid or viscous liquid
• 반응 적합성: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• 작용기: ester; maleimide
• 폴리머 구조: shape: linear; functionality: heterobifunctional
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: O=C(NCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O)CCN2C(C=CC2=O)=O

설명

특징 및 장점

MAL-dPEG^®₄-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG^® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

법적 정보

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable