추천 제품
형태
powder
포장
pkg of 1 × 10 mg (860498P-10mg)
pkg of 1 × 100 mg (860498P-100mg)
pkg of 1 × 25 mg (860498P-25mg)
제조업체/상표
Avanti Research™ - A Croda Brand
지질 유형
sphingolipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
InChI key
OTKJDMGTUTTYMP-ZWKOTPCHSA-N
일반 설명
Sphinganine (d18:0) is a substrate for the enzyme ceramide desaturase. It is synthesized indirectly due to the interconversion of supplemented glycine to serine. Sphinganine (d18:0) is catabolized to ceramide.
애플리케이션
Sphinganine (d18:0) has been used:
- as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides
- as a medium supplement to test its effect on growth of yeast cells
- in the preparation of bovine serum albumin lipid complex to investigate its effect on non-lysosomal - glucosylceramidase β2 (GBA2) inhibition
생화학적/생리학적 작용
Sphinganine (d18:0) levels are not altered in hereditary sensory neuropathy type 1 cells. Accumulation of d18:0 is observed in tumor hypoxia. It is useful as a biomarker for studying microbial diversity.
포장
5 mL Amber Glass Screw Cap Vial (860498P-100mg)
5 mL Amber Glass Screw Cap Vial (860498P-10mg)
5 mL Amber Glass Screw Cap Vial (860498P-25mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
또한 이 제품과 함께 일반적으로 구입
제품 번호
설명
가격
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Sunyoung Hwang et al.
Cell reports, 29(8), 2473-2488 (2019-11-21)
An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain largely unknown. Here, we show that aneuploidy disrupts
Altered sphingolipid metabolism induced by tumor hypoxia-new vistas in glycolipid tumor markers
Yin J, et al.
Febs Letters, 584(9), 1872-1878 (2010)
Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease
Schonauer S, et al.
Test, 292(15), 6177-6189 (2017)
Mirthe Muilwijk et al.
BMJ open diabetes research & care, 8(1) (2020-05-08)
People of South Asian origin are at high risk of type 2 diabetes (T2D), but the underpinning mechanisms are not fully understood. We determined ethnic differences in acylcarnitine, amino acid and sphingolipid concentrations and determined the associations with T2D. Associations
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Wang Z, et al.
The Journal of Investigative Dermatology, 133(3), 668-676 (2013)
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