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Merck
모든 사진(1)

Key Documents

178501

Sigma-Aldrich

Palmostatin B

≥95% (HPLC), solid, APT1 inhibitor, Calbiochem®

동의어(들):

APT1 Inhibitor, palmostatin B, APT1 Inhibitor

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About This Item

실험식(Hill 표기법):
C23H36O4
Molecular Weight:
376.53
UNSPSC 코드:
12352200
NACRES:
NA.77

product name

APT1 Inhibitor, palmostatin B, The APT1 Inhibitor, palmostatin B controls the biological activity of APT1.

Quality Level

분석

≥95% (HPLC)

형태

solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
protect from light

색상

off-white

solubility

DMSO: 100 mg/mL

배송 상태

wet ice

저장 온도

−20°C

일반 설명

A cell-permeable, beta-lactone acyl protein thioesterase 1 (APT1) inhibitor (IC50 = 0.67 µM, in an enzymatic assay) that is shown to specifically block Ras depalmitoylation, without affecting Ras acylation, in MDCK cells, both in vitro and in vivo. It induces a marked redistribution of NRas to endomembranes (1 µM) without notable cytotoxicity, and is shown to elicit a loss of the precise steady-state localization of palmitoylated Ras proteins in the same cell line. At 50 µM, this inhibitor displays a partial phenotypic reversion in oncogenic HRasG12V-transformed fibroblasts. Furthermore, it demonstrates selectivity for APT1 over phospholipase A1, A2, Cβ and D. It′s inhibitory effect is demonstrated to be consistent with that of APT1 downregulation by siRNA. Also available as a 50 mM solution in DMSO (Cat. No. 508738).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Dekker, F. and Hedberg, C. 2011. Bioorg. Med. Chem. Lett.19, 1376.
Dekker, F., et al. 2010. Nat. Chem. Biol.6, 449.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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