추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
serum
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
human, rat
제조업체/상표
Chemicon®
기술
immunohistochemistry: suitable
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... SLC6A2(6530)
일반 설명
The chemical compound norepinephrine (NC(8)O(3)H(11), also known as noradrenaline, is a catecholamine that functions as both a neurotransmitter and a hormone. It is released from the adrenal glands and also by certain neurons. It affects parts of the human brain where attention and impulsivity are controlled. This compound affects the fight-or-flight response, activating the sympathetic nervous system to directly increase heart rate, release energy from fat and increase muscle readiness.
The host of physiological changes activated by a stressful event are unleashed in part by activation of a nucleus in the brain stem called the locus ceruleus. This nucleus is the origin of most norepinephrine pathways in the brain. Neurons using norepinephrine as their neurotransmitter project bilaterally from the locus ceruleus along distinct pathways to the cerebral cortex, limbic system, and the spinal cord, among other projections.
The host of physiological changes activated by a stressful event are unleashed in part by activation of a nucleus in the brain stem called the locus ceruleus. This nucleus is the origin of most norepinephrine pathways in the brain. Neurons using norepinephrine as their neurotransmitter project bilaterally from the locus ceruleus along distinct pathways to the cerebral cortex, limbic system, and the spinal cord, among other projections.
특이성
Noradrenaline: reactive with noradrenaline reacted with glutaraldehyde; glutaraldehyde required in fixation for reactivity; reactivity with free noradrenaline is very poor.
The cross-reactivities were determined using either ELISA or RIA techniques, at concentration/unconjugated or conjugated amino acid concentration at half displacement.
Compound Cross-reactivity
Noradrenaline-G-BSA 1.0
Octopamine-G-BSA 0.032
Dopamine-G-BSA 0.016
Adrenaline-G-BSA 0.006
Noradrenaline 0.0002
L-Dopa-G-BSA 0.0002
p-Tryamine-G-BSA 0.0002
*The antisera was also tested for specificity using the free-floating PAP technique on rat locus coeruleus.
Abbreviations:
(BSA)= Bovine serum albumin
G)= Glutaraldehyde
The cross-reactivities were determined using either ELISA or RIA techniques, at concentration/unconjugated or conjugated amino acid concentration at half displacement.
Compound Cross-reactivity
Noradrenaline-G-BSA 1.0
Octopamine-G-BSA 0.032
Dopamine-G-BSA 0.016
Adrenaline-G-BSA 0.006
Noradrenaline 0.0002
L-Dopa-G-BSA 0.0002
p-Tryamine-G-BSA 0.0002
*The antisera was also tested for specificity using the free-floating PAP technique on rat locus coeruleus.
Abbreviations:
(BSA)= Bovine serum albumin
G)= Glutaraldehyde
면역원
Noradrenaline-glutaraldehyde-BSA
애플리케이션
Anti-Norepinephrine Antibody is an antibody against Norepinephrine for use in IH.
Immunohistochemistry: 1:200-1:500 with enhanced detection. Glutaraldehyde fixation required for reactivity. Lightly fixed 4% PFA .2-5% glutaraldehyde fixed tissue works well; permeabilization with 0.1-.2% triton X-100 in block ONLY. Dilute antibody solutions in simple buffers without excess proteins or detergents.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Hormones & Receptors
Hormones & Receptors
물리적 형태
Liquid rabbit antiserum with 0.05% sodium azide.
저장 및 안정성
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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