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Supelco

4′-Hydroxydiclofenac

VETRANAL®, analytical standard

동의어(들):

4′-Hydroxy Diclofenac, [2-(2,6-Dichloro-4-hydroxy-phenylamino)phenyl]acetic acid

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About This Item

실험식(Hill 표기법):
C14H11Cl2NO3
CAS Number:
Molecular Weight:
312.15
Beilstein:
4198042
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Grade

analytical standard

Quality Level

제품 라인

VETRANAL®

유통기한

limited shelf life, expiry date on the label

기술

HPLC: suitable
gas chromatography (GC): suitable

응용 분야

forensics and toxicology
pharmaceutical (small molecule)

형식

neat

저장 온도

2-8°C

SMILES string

OC(=O)Cc1ccccc1Nc2c(Cl)cc(O)cc2Cl

InChI

1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20)

InChI key

KGVXVPRLBMWZLG-UHFFFAOYSA-N

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일반 설명

4′-Hydroxydiclofenac is one of the metabolites of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used in human and veterinary medicine.
CYP2C9 metabolite of diclofenac.

애플리케이션

4′-Hydroxydiclofenac may be used as an analytical reference standard for the determination of the analyte in rat serum by high performance liquid chromatograph/ultraviolet method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

법적 정보

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

Skull and crossbonesCorrosionEnvironment

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3


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시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

Efficient high performance liquid chromatograph/ultraviolet method for determination of diclofenac and 4?-hydroxydiclofenac in rat serum.
Kaphalia L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 830(2), 231-237 (2006)
Lian-Hua Xu et al.
Applied microbiology and biotechnology, 99(7), 3081-3091 (2014-10-25)
Diclofenac is a nonsteroidal anti-inflammatory drug. It undergoes hydroxylation by mammalian cytochrome P450 enzymes at 4'- and/or 5'-positions. A bacterial P450 enzyme, CYP105D7 from Streptomyces avermitilis, has been shown to catalyze hydroxylation of 1-deoxypentalenic acid and an isoflavone daidzein. Here
M-Y Lee et al.
The pharmacogenomics journal, 14(4), 343-349 (2013-12-11)
Cytochrome P450 2C9 (CYP2C9) metabolizes many clinically important drugs including warfarin and diclofenac. We have recently reported a new allelic variant, CYP2C9*35, found in a warfarin hypersensitive patient with Arg125Leu and Arg144Cys mutations. Here, we have investigated the molecular basis

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