360589

Tetrahydrofuran

≥99.0%, ACS reagent, contains 250 ppm BHT as inhibitor, suitable for HPLC

• 동의어(들): THF, Butylene oxide, Oxolane, Tetramethylene oxide
• 실험식(Hill 표기법): C₄H₈O
• CAS Number: 109-99-9
• Molecular Weight: 72.11
• Beilstein: 102391
• EC Number: 203-726-8
• MDL number: MFCD00005356
• UNSPSC 코드: 12191501
• PubChem Substance ID: 329755267
• NACRES: NA.21

속성

• product name: Tetrahydrofuran, contains 250 ppm BHT as inhibitor, ACS reagent, ≥99.0%
• Grade: ACS reagent
• Quality Level: 200
• vapor density: 2.5 (vs air)
• vapor pressure: 114 mmHg ( 15 °C); 143 mmHg ( 20 °C)
• 분석: ≥99.0%
• 형태: liquid
• autoignition temp.: 610 °F
• 포함: 250 ppm BHT as inhibitor
• expl. lim.: 1.8-11.8 %
• 기술: HPLC: suitable
• 불순물: ≤0.015% peroxide (as H₂O₂); ≤0.05% water
• 증발 잔류물: ≤0.03%
• 색상: APHA: ≤20
• refractive index: n20/D 1.407 (lit.)
• pH: ~7
• bp: 65-67 °C (lit.)
• mp: −108 °C (lit.)
• solubility: water: soluble
• density: 0.889 g/mL at 25 °C (lit.)
• SMILES string: C1CCOC1
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
• InChI key: WYURNTSHIVDZCO-UHFFFAOYSA-N

설명

일반 설명

Tetrahydrofuran (THF) is a heterocyclic compound (cyclic ether). It is colorless, has low viscosity, and good solubility in a wide range of solvents. It is widely used as a solvent in organic synthesis, being very popular in reactions with organometallic compounds and Grignard reagents. Due to organic peroxides formation on long term storage, THF is usually stabilized by adding butylated hydroxytoluene (BHT). BHT removes the free radicals required for the peroxide formation.

애플리케이션

Tetrahydrofuran (THF) is used as a solvent in the following processes:

• Organic synthesis

a) Grignard
b) Organometallic compounds
c) Reformatsky
d) Lithiation
e) Hydride reduction
f) Metal-catalyzed coupling (Heck, Stile, Suzuki)
g) Lewis acid mediated reactions

• Crystallization
• Polymerization. Ex. RAFT (Reversible Addition-Fragmentation Chain Transfer) polymerization of p-acetoxystyrene
• Coatings
• As an O-donor ligand to form coordination complexes
• As mobile phase solvent in high-performance liquid chromatography

특징 및 장점

ACS solvents meet or exceed the high standards of the American Chemical Society (ACS),with test specifications that are specialized to every compound. According to the American Chemical Society, ACS reagent grade implies that it is a substance of sufficient purity to be used in most chemical analyses or reactions.

기타 정보

Go to our Greener Alternative-2-Methyl Tetrahydrofuran - 155810

Go to our Greener Alternative-Cyclopentyl methylether - 675989

안전성 정보

• 픽토그램: GHS02,GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H302,H319,H335,H336,H351
• 예방조치 성명서: P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• 표적 기관: Central nervous system, Respiratory system
• 보충제 위험성: EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point (°F): -6.2 °F - closed cup
• Flash Point (°C): -21.2 °C - closed cup