추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen ~36 kDa
종 반응성
human, mouse, rat
기술
immunoprecipitation (IP): 5-10 μL using rat NRK cell lysate
western blot: 2-4 μg/mL using whole extracts of human HeLa and mouse 3T3 cells
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ATG3(64422)
mouse ... Atg3(67841)
관련 카테고리
일반 설명
ATG3 is a member of the autophagy-related protein family and is involved in the formation of the autophagosome.
Autophagy-related protein 3 (ATG3) is a member of the autophagy-related protein family. It is a mammalian homolog of yeast Apg3p/ Atg3 is ubiquitously expressed in human tissues.
면역원
synthetic peptide corresponding to amino acids 17-32 of human Atg3, conjugated to KLH via a C-terminal cysteine residue. The corresponding sequence is identical in rat and mouse.
애플리케이션
Anti-ATG3 antibody produced in rabbit has been used in western blotting and immunoprecipitation.
생화학적/생리학적 작용
Autophagy-related protein 3 (ATG3) is involved in the formation of the autophagosome. the mammalian homolog of yeast Apg3p/Aut1p, is an E2-like enzyme that catalyzes the conjugation reaction between Atg8 and phosphatidylethanolamine (PE). Golgi-associated ATPase enhancer of 16 kDa (GATE-16), GABAA receptor-associated protein (GABARAP), and microtubule-associated protein light chain 3 (MAP-LC3) are substrates for Atg3. MAP-LC3 is the preferred substrate. Atg3 interacts with Atg7 to form an E1-E2 complex, and with Atg12, which is a substrate for Atg7 but not for Atg3. Moreover, overexpression of Atg3 facilitates the formation of the Atg12-Atg5 conjugate.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function
Murrow L, et al.
Nature Cell Biology, 17(3), 300-300 (2015)
The transcription and translation landscapes during human cytomegalovirus infection reveal novel host-pathogen interactions
Tirosh O, et al.
PLoS Pathogens, 11(11), e1005288-e1005288 (2015)
Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12
Metlagel Z, et al.
Proceedings of the National Academy of Sciences of the USA, 110(47), 18844-18849 (2013)
Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins
Agrotis A, et al.
The Journal of Biological Chemistry, 294(34), 12610-12621 (2019)
Hila Winer et al.
Nature communications, 9(1), 3744-3744 (2018-09-16)
Autophagy, a conserved membrane trafficking process, sequesters cytoplasmic components into autophagosomes and targets them for lysosomal degradation. The TNF receptor Fn14 participates in multiple intracellular signaling pathways and is strongly induced upon tissue injury and solid tumorigenesis. While Fn14 is
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