F0503

5-Fluoro-2′-deoxyuridine

thymidylate synthase inhibitor

• 동의어(들): floxuridine, 2′-Deoxy-5-fluorouridine, FUDR, Floxuridine
• 실험식(Hill 표기법): C₉H₁₁FN₂O₅
• CAS Number: 50-91-9
• Molecular Weight: 246.19
• Beilstein: 90221
• EC Number: 200-072-5
• MDL number: MFCD00006530
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24894724
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• 분석: ≥99% (HPLC)
• 형태: powder
• mp: 148 °C (lit.)
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• 저장 온도: room temp
• SMILES string: OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O
• InChI: 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
• InChI key: ODKNJVUHOIMIIZ-RRKCRQDMSA-N
• 유전자 정보: human ... TYMS(7298) ; mouse ... Tyms(22171)

설명

일반 설명

5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers.

애플리케이션

5-Fluoro-2′-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.

생화학적/생리학적 작용

Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves