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Merck
모든 사진(4)

Key Documents

L9150

Sigma-Aldrich

N-Lauroylsarcosine sodium salt

detergent for use in cell lysis

동의어(들):

Sodium lauroyl sarcosinate, N-Dodecanoyl-N-methylglycine sodium salt, Sarkosyl NL

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About This Item

Linear Formula:
CH3(CH2)10CON(CH3)CH2COONa
CAS Number:
Molecular Weight:
293.38
Beilstein:
5322974
EC Number:
MDL number:
UNSPSC 코드:
12161902
PubChem Substance ID:
NACRES:
NA.52

Grade

for molecular biology

설명

anionic

제품 라인

BioReagent

분석

≥94%

형태

powder

분자량

micellar avg mol wt 600

응집 번호

2

기술

protein purification: suitable
protein quantification: suitable

CMC

14.6 mM (20-25°C)

solubility

H2O: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

외래 활성

DNase, RNase, none detected

저장 온도

room temp

SMILES string

[Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O

InChI

1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19;/h3-13H2,1-2H3,(H,18,19);/q;+1/p-1

InChI key

KSAVQLQVUXSOCR-UHFFFAOYSA-M

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일반 설명

Sodium lauroyl sarcosinate, the sodium salt of an acyl derivative of sarcosine—a natural amino acid occurring in muscles and body tissues—stands out as a valuable component in molecular biology, biochemical, and cell biology research. Derived from a natural fatty acid and the amino acid derivative sarcosine, N-Lauroylsarcosine is a biodegradable anionic surfactant usually synthesized through acylation and neutralization reactions involving lauric acid and sodium sarcosine.

This amino acid-type anionic surfactant, also recognized as a fatty acid amide and detergent, exhibits protein denaturant potency and has been integrated into lysing solutions, such as the cornet assay. Its application extends to lysing protoplasts for chromosomal DNA isolation from Streptococcus mutans. Notably, Lauroylsarcosine Sodium Salt, characterized by its ionic detergent properties, is commonly employed for purifying membrane proteins. Additionally, Sodium Lauroyl Sarcosine also plays a crucial role in concentrated salt solutions, facilitating cell lysis in RNA purification protocols and membrane solubilization. Whether it′s breaking down cell structures or facilitating membrane protein purification, this mild surfactant proves valuable in various applications within the realms of biology and biochemistry.

애플리케이션

Suitable for
  • solubilization and separation of membrane proteins
  • lysis of cells during the isolation of RNA
  • inhibition of hexokinase

특징 및 장점

  • Suitable for Molecular Biology, Biochemical and Cell Biology research
  • Can be used for Protein Purification and Quantification
  • High purity product for research applications

기타 정보

Anionic surfactant.
For additional information on our range of Biochemicals, please complete this form.

픽토그램

Skull and crossbonesCorrosion

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flash Point (°F)

512.6 °F - closed cup

Flash Point (°C)

267 °C - closed cup

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

M Swenshon et al.
Journal of clinical microbiology, 36(7), 1902-1906 (1998-07-03)
The present study was designed to identify and comparatively investigate 35 beta-hemolytic streptococci isolated from stranded harbor porpoises or from animals caught in fishing nets of the North and Baltic seas. According to biochemical and serological data and to lectin
A R Günthert et al.
The Journal of cell biology, 134(4), 1089-1096 (1996-08-01)
Ligation of CD95 (APO-1/Fas) cell surface receptors induces death in apoptosis-sensitive cells. Induction of apoptosis in adherent gamma interferon-stimulated HT-29 and COLO 205 colon carcinoma cells by cross-linking CD95 with anti-APO-1 monoclonal antibody resulted in detachment of the cells from
Rhonda I Hobb et al.
Microbiology (Reading, England), 155(Pt 3), 979-988 (2009-02-28)
Although infection with Campylobacter jejuni is one of the leading causes of gastroenteritis worldwide, relatively little is known about the factors that are required to elicit a protective immune response. The need for a vaccine against this pathogen is well
Joanna A Korecka et al.
PloS one, 8(5), e63862-e63862 (2013-06-01)
Multiple genetic and environmental factors play a role in the development and progression of Parkinson's disease (PD). The main neuropathological hallmark of PD is the degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta. To study genetic and
Nadine Schrode et al.
Nature genetics, 51(10), 1475-1485 (2019-09-25)
The mechanisms by which common risk variants of small effect interact to contribute to complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic human induced pluripotent stem cells, to evaluate the effects of schizophrenia (SZ)-associated common

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