M9170
Macrophage Colony-Stimulating Factor from mouse
≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
동의어(들):
mCSF-1, mM-CSF, CSF-1, M-CSF
로그인조직 및 계약 가격 보기
모든 사진(2)
About This Item
CAS Number:
EC Number:
MDL number:
UNSPSC 코드:
12352202
eCl@ss:
32190102
NACRES:
NA.77
추천 제품
product name
Macrophage Colony-Stimulating Factor from mouse, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Quality Level
UniProt 수납 번호
유전자 정보
mouse ... Csf1(12977)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
Macrophage Colony-Stimulating Factor from mouse has been used:
- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
생화학적/생리학적 작용
Macrophage Colony Stimulating Factor (M-CSF), also known as CSF-1, can be produced by a number of cells, including fibroblasts, monocytes, activated macrophages, secretory epithelial cells of the endometrium, endothelial cells activated by LPS or cytokines, and bone marrow stromal cells. In addition to its namesake activity, M-CSF can stimulate the proliferation of isolated macrophages, augment the production and release of cytokines and other inflammatory modulators from macrophages, enhance macrophage antibody-dependent cell-mediated cytotoxicity, prime and enhance macrophages in their ability to kill tumor cells and other microorganisms, stimulate pinocytosis, and support osteoclast differentiation. M-CSF binds and activates a 165 kDa glycoprotein of the receptor tyrosine kinase subclass III or the RTK subfamily. Due to alternative splicing of a single M-CSF gene and due to variations in glycosylation, the molecular weight of natural soluble M-CSF ranges from 44-86 kDa. Human and mouse M-CSF share approximately 80% sequence homology in the conserved N-terminal region of 150 amino acids. Although human M-CSF is active in murine systems, mouse M-CSF appears to be species-specific in its actions.
물리적 형태
Lyophilized from a sterile filtered buffered aqueous solution.
분석 메모
The proliferative activity is tested by the dose-dependent stimulation of the murine monocytic cell line, M-NFS-60.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Rapid Rapamycin-only induced osteogenic differentiation of blood-derived stem cells and their adhesion to natural and artificial scaffolds
Arianna C, et al.
Stem Cells International, 2017 (2017)
Strain differences in the attenuation of bone accrual in a young growing mouse model of insulin resistance
Rendina-Ruedy E, et al.
Journal of Bone and Mineral Metabolism, 34(4), 380-394 (2016)
Yan Li et al.
Journal of immunology (Baltimore, Md. : 1950), 191(6), 3192-3199 (2013-08-13)
Engraftment of human CD34⁺ hematopoietic stem/progenitor cells into immunodeficient mice leads to robust reconstitution of human T and B cells but not monocytes and macrophages. To identify the cause underlying the poor monocyte and macrophage reconstitution, we analyzed human myeloid
Verena Turco et al.
Nature communications, 14(1), 771-771 (2023-02-12)
Glioblastoma, the most common and aggressive primary brain tumor type, is considered an immunologically "cold" tumor with sparse infiltration by adaptive immune cells. Immunosuppressive tumor-associated myeloid cells are drivers of tumor progression. Therefore, targeting and reprogramming intratumoral myeloid cells is
Tobias A Bauer et al.
Advanced healthcare materials, 10(19), e2100385-e2100385 (2021-06-18)
Iron is an essential co-factor for cellular processes. In the immune system, it can activate macrophages and represents a potential therapeutic for various diseases. To specifically deliver iron to macrophages, iron oxide nanoparticles are embedded in polymeric micelles of reactive
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